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<正> “ras”这名字是由于该基因首先在大鼠肉瘤病毒(rat sarcoma virus)中发现而得。1964年,英国学者Harvey在做莫尼氏致白血病病毒(Moloney’s leukemogeic virusMLV)传代时,用一种大鼠血浆(该大鼠在出生时接种了含有MLV的小鼠血浆),注射到15只新生的小鼠体内。结果发现,在32天内存活的6只小鼠中有5只在注射部位或附近长出肉瘤。后来发现使小鼠发生肉瘤的转化基因ras,并不是这种肉瘤病毒株特有的,它也是大鼠的正常细胞基因。另外,在一系列细胞恶性转化试验中,用从
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[1]樊可同.ras基因及ras蛋白[J].广州医学院学报,1992(03):68-72.
1992-09-30
1992-09-30