广州医科大学学报

目的:探讨甘露醇联合泽通治疗急性脑梗死患者术后脑水肿的临床效果。方法:将2012年6月至2014年9月收治的急性脑梗死术后脑水肿患者随机分成两组,对照组行单纯性甘露醇治疗,实验组施以泽通+甘露醇联合治疗,对比两组临床效果。结果:实验组总有效率94.74%vs 78.95%,明显高于对照组,治疗7、10 d后NIHSS评分(5.11±2.76)分vs(7.13±2.08)分;(4.02±2.71)分vs(6.81±2.67)分,均低于对照组,且D级脑水肿所占比例5.26%vs 28.95%,显著低于对照组,两组比较差异有统计学意义(P<0.05)。结论:急性脑梗死后脑水肿患者行苏尼联合甘露醇疗法,能有效调节患者神经功能,缓解脑水肿,改善其预后,值得临床推广。

Objective: To explore the clinical efficacy of combined treatment with Torasemide and mannitol for postoperative brain edema in patients with acute cerebral infarction. Methods: Patients with postoperative brain edema after acute cerebral infarction between June 2012 and September 2014 were recruited as subjects. Of these patients,76 were randomly selected and divided into two groups,namely,the control group to receive mannitol alone,and the study to receive combination therapy with Torasemide and mannitol. The therapeutic efficacy was compared between the two groups. Results: The study group showed significantly higher rate of effectiveness( 94.74% vs 78.95%),and lower NIHSS scores on days 7( 5.11±2.76 vs 7.13±2.08) and 10( 4.02±2.71 vs 6. 81 ± 2. 67),compared with the control group. Moreover,grade-D brain edema accounted for lower proportion of patients in the study group than in the control group( 5. 26% vs 28. 95%),with statistically significant difference( P<0.05). Conclusion: Combined treatment with Torasemide and mannitol in postoperative brain edema after acute cerebral infarction may effectively modify the neural functioning,alleviate brain edema,and improve the outcomes in these patients,therefore is justified for widespread use in clinical practice.