广州医科大学学报

目的:观察复方谷氨酰胺颗粒联合肠内营养治疗溃疡性结肠炎(UC)的疗效。方法:对本院2014年1月至2015年12月收治确诊UC 181例患者,联合用药组(n=59):复方谷氨酰胺颗粒口服,0.67 g/次,每天3次+肠内营养混悬液(能全力)500 m L每天1次,4周1个疗程;复方谷氨酰胺组(n=62):复方谷氨酰胺颗粒660 mg/次,每天3次,4周1个疗程;能全力组(n=60):能全力500 m L每天1次,4周1个疗程。患者在治疗前及≥4周后进行电子肠镜检查,观察患者的腹痛、腹胀、纳差、腹泻、血便等主要症状、营养体征变化及不良反应等指标。结果:治疗4周后观察,联合用药组患者的腹痛、腹胀、纳差、腹泻、血便等症状均比复方谷氨酰胺组及能全力组明显改善(P<0.05);联合用药组的白蛋白、总蛋白、体质指数等营养指标均比复方谷氨酰胺组、能全力组明显改善(P<0.05);联合用药组与复方谷氨酰胺组、能全力组的总有效率差异有统计学意义(P<0.05);联合用药组的不良反应发生率与能全力组的发生率相当。结论:复方谷氨酰胺颗粒联合肠内营养治疗UC比单一药物优势明显。

Objective: To investigate the effect of compound Glutamine granules and enteral nutrition in the treatment of ulcerative colitis( UC). Methods: A total of 181 patients,diagnosed with UC and hospitalized in our hospital between January 2014 and December 2015,were included in the study. Combination therapy group( n =59) received 1g compound Glutamine granules,thrice daily + 500 m L enteral nutrition suspensions,once daily.Compound Glutamine group( n = 62) received 1g compound Glutamine granules,thrice daily. Nutrison group( n= 60) received 500 m L Nutrison,once daily. The treatments lasted 4 weeks. All patients underwent electronic colonoscopy before the treatment and ≥ 4 weeks after the treatment. The major symptoms( abdominal pain,bloating,anorexia, diarrhea and bloody stools), changes of nutritional sign, and adverse reactions were determined. Results: At 4 weeks after the treatment,the symptoms of abdominal pain,bloating,anorexia,diarrhea and bloody stools in the combination therapy group were significantly improved than those in the LGlutamine group and nutrison group( P < 0. 05). The nutrition indicators of albumin,total protein and body mass index in the combination therapy group were significantly improved than those in the compound Glutamine group and nutrison group( P < 0. 05). There was statistically significant difference in the total effective rate among the combination therapy group,compound Glutamine group and nutrison group( P < 0. 05). There was no significant difference in the incidence of adverse reactions between the combination therapy group and nutrison group. Conclusion: The advantages of using compound Glutamine granules and enteral nutrition in the treatment of UC were more significant than those using single drug.