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目的:探讨术前静脉注射维拉帕米对腹腔镜胆囊切除术(LC)患者氧化应激反应的影响。方法:收集2007年1月至2008年10月广东省深圳市人民医院收治的30例行择期LC的慢性胆囊炎并胆囊结石患者的临床资料,将患者随机分为对照组和维拉帕米组,每组15例。分别测定两组患者术前(T1)、手术气腹结束即刻(T2)及术后24 h(T3)血清ALT、AST和丙二醛(MDA)的浓度。结果:与T1时相点比较,两组患者T2、T3时相点ALT和AST值均增高(P<0.05),维拉帕米组患者T2、T3时相点ALT和AST值增高幅度明显低于对照组(P<0.01);与T1时相点比较,对照组患者T2、T3时相点MDA值增高显著(P<0.05),维拉帕米组患者T2、T3时相点MDA值明显低于对照组(P<0.01)。结论:术前静脉注射维拉帕米能有效减小气腹带来的氧化应激反应,有效保护肝脏等脏器的功能。
Abstract：Objective:To evaluate the impact of verapamil on oxidative stress reaction in patiens undergoing laparoscopic cholecystectomy(LC ).Methods:Between January 2007 and October 2008,30 patients with chronic cholecystitis and gallstone undergoing elective LC in Shenzhen People's Hospital of Guangdong province were randomly divided into control and verapamil groups(n = 15 each).The concentrations of serum ALT,AST and malondialdehyde(MDA) at the time spots of(T1) before surgery,(T2 ) after surgery and(T3 ) 24h after surgery were determined in both two groups,respectively.Results:In both two groups,the ALT and AST values were increased at T2 and T3 time spots as compared with those at T1(P<0.05 ).Notably,the increased ALT and AST values at T2 and T3 in verapamil group were much lower than those in control group(P<0.01 ).The MDA value at T2 and T3 was significantly higher in control group as compared with that at T1(P<0.05 ),and the MDA value at T2 and T3 in verapamil group was obviously lower than that in control group(P<0.01 ). Conclusion:The preoperative intravenous injection of verapamil could effectively reduce oxidative stress caused by pneumoperitoneum and protect the functions of liver.
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基本信息:
中图分类号:R614
引用信息:
[1]王玉梅,石碧明,海超.维拉帕米对腹腔镜胆囊切除术氧化应激反应的影响[J].广州医学院学报,2012,40(02):34-36.
2012-04-15
2012-04-15