广州医科大学学报

目的：探讨曲克芦丁联合康复理疗治疗缺血性脑卒中（IS）的临床疗效。方法：选择2021年1月至2023年1月本院收治的IS患者150例为研究对象，随机数表法分对照组和观察组，每组75例。对照组给予常规康复理疗干预，观察组在此基础上联合曲克芦丁治疗，均连续治疗12 d。比较两组临床疗效，记录治疗前后美国国立卫生研究院卒中量表（NIHSS）评分、巴氏指数（BI）、血清微RNA-137(miR-137)、miR-155及C反应蛋白（CRP）、白细胞介素6(IL-6)水平，统计两组不良反应发生情况。结果：观察组和对照组治疗总有效率分别为93.3%(70/75)、80.0%(60/75)，组间比较差异有统计学意义（P<0.05）。治疗后两组NIHSS评分均较治疗前降低，且观察组低于对照组（均P<0.05）。治疗后两组BI均较治疗前升高，且观察组高于对照组（均P<0.05）。治疗后两组血清miR-137水平均较治疗前升高，且观察组高于对照组（均P<0.05）。治疗后两组血清miR-155水平均较治疗前降低，且观察组低于对照组（均P<0.05）。治疗后两组血清CRP、IL-6水平均较治疗前降低，且观察组低于对照组（均P<0.05）。观察组不良反应发生率显著低于对照组（6.67%比18.67%,P<0.05）。结论：曲克芦丁联合康复理疗治疗IS患者临床疗效较好。

Objective:To investigate the clinical efficacy of troxerutin combined with rehabilitation physiotherapy in the treatment of ischemic stroke(IS).Methods:A total of 150 patients with IS admitted to our hospital from January 2021 to January 2023 were selected,and divided into control group and observation group by random number table method,with 75 cases in each group. The control group received routine rehabilitation physiotherapy intervention,and the observation group was treated with troxerutin on the basis of the control group. Both groups were treated continuously for 12 days. The clinical efficacy of the two groups was compared. The National Institutes of Health Stroke Scale(NIHSS)score,Barthel index(BI),serum microRNA-137(miR-137),miR-155,Creactive protein(CRP)and interleukin-6(IL-6)levels were recorded before and after treatment,and the incidence of adverse reactions in the two groups was analyzed.Result:The total effective rates of the observation group and the control group were 93.3 %(70/75)and 80.0 %(60/75),respectively,with a significant difference(P<0.05). After treatment,the NIHSS scores of the two groups were lower than those before treatment,and the observation group was lower than the control group(all P<0.05). After treatment,the BI of the two groups were higher than those before treatment,and the observation group was higher than the control group(all P<0.05). After treatment,the levels of serum miR-137 in the two groups were higher than those before treatment,and the observation group was higher than the control group(all P<0.05). After treatment,the levels of serum miR-155 in the two groups were lower than those before treatment,and the observation group was lower than the control group(all P<0.05). After treatment,the levels of serum CRP and IL-6 in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(all P<0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group(6.67 % vs 18.67 %,P<0.05).Conclusions:The clinical effect of troxerutin combined with rehabilitation physiotherapy in the treatment of IS patients is better.