广州医科大学学报

目的: 探讨艾司洛尔对支撑喉镜引起的心血管反应的预防作用。方法:患者40例随机分为艾司洛尔组(E组)和对照组(N组),每组各20例。全麻诱导气管插管后艾司洛尔组在置入支撑喉镜前2min静脉滴注艾司洛尔2. 0mg/kg,然后以100μg/(kg·min)速度持续泵输注直至支撑喉镜取出时停药。两组全麻用药相同,监测并记录麻醉诱导前、麻醉诱导后、置入支撑喉镜时、置入支撑喉镜后5min、退出支撑喉镜后5min的HR、SBP、DBP。记录麻醉时间和手术时间。测得数据进行统计学处理。结果:艾司洛尔组在置入支撑喉镜时、置入支撑喉镜后5min的心率、血压升高数值明显少于对照组。其余各时间点两组差异无显著性。结论:艾司洛尔能安全有效地抑制支撑喉镜下声带小节摘除术中置入支撑喉镜引起的心血管不良反应。

Objective:to study the cardiovascular protective effect by Esmolol during anesthesia for excision of vocal nodules under suspension laryngoscopy. Methods: forty patients were divided randomly into Esmolol group (group E) and control group (group C), 20 in each. For group E, after induction and intubation for general anesthesia and prior to insertion of suspension laryngoscope, 2.0 mg/kg of Esmolol was injected intravenously followed by dose maintenance at a speed of 100 ug/(kg·min -1 ) until withdrawal of laryngoscope. HR, SBP and DBP of the both groups before and after induction, at minutes 0, 5 of laryngoscope insertion and 5 minutes after laryngoscopy withdrawal were monitored and recorded. Time duration for anesthesia and operation was also recorded. Results: HR and Bp changes from baseline in group E at minutes 0, 5 of laryngoscope insertion and 5 minutes after laryngoscopy withdrawal were significantly lower as compared with controls. Differences at other time spots between the two groups were unremarkable. Conclusion: Esmolol was safe and effective to prevent cardiovascular events during anesthesia for excision of vocal nodules under suspension laryngoscopy.