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目的：探讨阿加曲班联合奥拉西坦治疗对急性脑梗死患者血液中炎性因子水平的影响。方法：将128例急性脑梗死患者随机分为联合治疗组（n=66）和对照组（n=62）。对照组采用奥拉西坦3 g（生理盐水250 mL稀释）静脉滴注，1次/天。联合治疗组在对照组基础上给予阿加曲班，治疗前2天每天60 mg(500 mL生理盐水稀释)，24 h持续静脉滴注；后5天每天10 mg(250 mL生理盐水稀释)，早晚2次持续静脉滴注，每次约3 h。观察两组治疗后2周血清IL-1β、IL-6、TNF-α、CRP、NT-proBNP水平变化。结果：治疗后，两组血清IL-1β、IL-6、TNF-α、CRP、NT-proBNP水平均较治疗前下调（均P<0.05），其中联合治疗组IL-6、TNF-α下降程度更大（均P<0.05）。结论：阿加曲班联合奥拉西坦有助于降低急性脑梗死患者相关血清炎性细胞因子水平。
Abstract：Objective:To investigate the effects of argatroban combined with oxiracetam on serum inflammatory cytokines levels in patients with acute cerebral infarction.Methods:A total of 128 patients with acute cerebral infarction were randomized into the combination treatment group(n= 66)and the control group(n= 62). The control group received intravenous oxiracetam 3 g(diluted in 250 mL normal saline)once daily.In addition to this,the combination treatment group was given argatroban at a daily dose of 60 mg(diluted in 500mL normal saline)by 24 h continuous intravenous infusion during the first 2 days of treatment,then switched to a daily dose of 10 mg(diluted in 250 mL normal saline)by two continuous intravenous infusion sessions over 3h each in the morning and evening,during the next 5 days. The changes in serum IL-1β,IL-6,TNF-α,CRP and NT-proBNP levels in the two groups after treatment were recorded.Results:After treatment,the serum levels of IL-1β,IL-6,TNF-α,CRP,and NT-proBNP were all down-regulated in either group compared with baseline(all P<0.05). In particular,the reductions in IL-6 and TNF-α were more pronounced in the combination treatment group(bothP<0.05).Conclusion:Argatroban combined with oxiracetam can help reduce the levels of serum inflammatory cytokines in patients with acute cerebral infarction.
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基本信息:
中图分类号:R743.33
引用信息:
[1]何大伟,黎宇华,陈如冲,等.阿加曲班联合奥拉西坦对急性脑梗死血清炎性因子水平的影响[J].广州医科大学学报,2022,50(03):76-80.