广州医科大学学报

目的:探讨硝苯地平联合硫酸镁对子痫前期患者血压控制及妊娠结局的治疗效果。方法:病例回顾性分析2016年1月至2017年12月于我院妇产科就诊的子痫前期患者60例,均给予硝苯地平和硫酸镁治疗,比较治疗前后的治疗效果、血压水平、蛋白尿情况,观察妊娠结局以及药物不良反应发生情况。结果:治疗总有效率为86.67%。所有患者治疗后3天、7天的收缩压和舒张压、尿蛋白含量均低于治疗前(P<0.05)。观察期内不良反应发生率为26.67%。不良妊娠结局中,剖宫产88.33%,早产11.67%。结论:硝苯地平联合硫酸镁治疗子痫前期患者,可以有效控制血压,减轻蛋白尿,效果良好。

Objective: To investigate the therapeutic effect of nifedipine combined with magnesium sulfate on blood pressure control and pregnancy outcome in patients with preeclampsia. Methods: A retrospective analysis of 60 patients with preeclampsia from January 2016 to December 2017 in our department of obstetrics and gynecology was conducted. The patients were treated with nifedipine and magnesium sulfate. The therapeutic effect,blood pressure and proteinuria before and after treatment were compared. Pregnancy outcomes and adverse drug reactions were recorded. Results: The total effective rate of treatment was 86.67%. The systolic and diastolic blood pressures and urine protein level of all patients at 3 d and 7 d post treatment were lowered compared with baseline( P<0.05). The incidence of adverse drug reactions during the study period was 26.67%. In the adverse pregnancy outcome,cesarean section account for 88. 33% and premature delivery for 11. 67% of the cases.Conclusion: Nifedipine combined with magnesium sulfate in the treatment of pre-eclampsia patients can effectively control blood pressure and reduce proteinuria with good efficacy.