广州医科大学学报

目的:探讨国产与进口碘克沙醇在心血管高危人群冠脉造影和介入治疗中的效果和安全性。方法:将2014年1月至2015年12月广东省第二人民医院收治的226例心血管高危人群作为研究对象,随机分为国产组(国产碘克沙醇)和进口组(进口碘克沙醇),每组各113例,观察两组患者的造影效果、手术前后肾功能变化情况。结果:国产组和进口组患者不良反应发生率、造影总有效率分别为3.54%和2.85%、97.34%和98.23%,两组比较,差异均无统计学意义(均P>0.05);国产组患者血尿素氮(BUN)、血肌酐(Scr)、血尿素等肾功能指标治疗前后差异无统计学意义(P>0.05)。结论:国产碘克沙醇注射液在冠脉造影和介入治疗高危心血管人群的过程中造影效果优良、安全性比较高,且价位低廉,可在临床范围内推广使用。

Objective: To explore the efficacy and safety of domestic vs imported iodixanol in coronary angiography and interventional therapy among high-risk individuals for cardiovascular diseases. Methods:Included in this study were 226 high-risk individuals for cardiovascular diseases treated at the Second People' s Hospital of Guangdong Province between January 2014 and December 2015. The subjects were randomly divided into domestic agent group( using domestic iodixanol) and imported agent group( using imported iodixanol),with113 subjects in each group. The two groups were compared for contrasted imaging and changes in renal function before and after procedure. Results: The rates adverse reactions and total efficiency of angiography 3. 54% vs2. 85%,and 97. 34% vs 98. 23%,in the domestic agent group vs imported agent group respectively,with no statistically significant difference between the groups( P > 0. 05). After the procedure,patients in the domestic agent group did not show any statistically significant change in renal function parameters( including BUN,Scr and blood urea) from baseline( P > 0. 05). Conclusion: Domestic iodixanol injection is with satisfactory imaging efficiency,good safety and lower medical cost in coronary angiography and interventional therapy among high-risk individuals for cardiovascular diseases,and therefore is justified for widespread use in clinical practice.