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目的:以原发性高血压大鼠(spontaneously hypertensive rats,SHR)为实验模型,观察单纯使用阿托伐他汀钙对SHR血压、左室功能的影响,并探讨其相关机制。方法:10周龄雄性大鼠共30只,其中实验对照组21只,正常对照组9只。按实验和对照的原则分为3组:正常对照组(WKY),实验对照组(SHR),阿托伐他汀钙组[SHR-A,SHR服阿托伐他汀钙50 mg/(kg.d)],饲养16周后观察鼠尾收缩压(SBP),有创心功能,左心室心肌肥厚指数(LVM I),血浆内皮素-1(ET-1),肌浆网Ca2+-ATP酶活性(SERCA)。两组间资料的比较采用t检验和方差分析(ANOVA)。结果:SHR-A组较SHR组SBP低17.11 mmHg;左室等容舒张期室内压下降的时间常数(T)显著降低[(1.02±0.04)m svs(2.38±0.59)m s,P<0.05];LVM I有明显下降[(3.08±0.20)mg/gvs(3.31±0.23)mg/g,P<0.05]。ET-1有明显降低[(131.94±26.84)pg/mLvs(196.96±38.87)pg/mL,P<0.001],SERCA活性稍有升高。结论:阿托伐他汀钙治疗对延缓SHR血压的上升产生一定影响,有助于改善SHR左心室舒张功能,有助于抑制SHR左室肥厚。
Abstract：Objective:To observe the effects of atorvastatin calcium on systolic blood pressure(SBP), left ventricular function and the change of left ventricular hypertrophy in spontaneously hypertensive rats(SHR) and investigate the mechanism of this functional changes.Methods: The male SHRs(n=21) and WKYs(n=9) at 10 weeks of age were divided into 3 groups: the normal control group(WKY group),experimental control group(SHR group,n=10),and SHR-A group [SHR treated with atorvastatin 50 mg/(kg·d),n=11].After 16-week therapy,the rats were studied for tail-cuff systolic blood pressure(SBP),invasive left ventricular function,left ventricle mass index(LVMI),serum level of endothelin-1(ET-1) and the activity of sarcoplasmic reticulum Ca2+-ATPase(SERCA) in left ventricle.Comparison between two groups was done by t test and analysis of variance.Results: Compared with SHR group,SHR-A rats showed reduction of SBP by 17.11 mmHg,significantly lowered time constant of left ventricular relaxation [(1.02±0.04) ms vs(2.38±0.59) ms,P<0.05],left ventricle mass index(LVMI) [(3.08±0.20) mg/g vs(3.31±0.23) mg/g,P<0.05] and serum level of ET-1 [(131.94±26.84) pg/ml vs(196.96±38.87) pg/ml,P<0.001].The activity of SERCA in left ventricle was a bit higher in SHR-A.Conclusion: Therapy with atorvastatin showed effects to delay blood pressure increasing in SHR,which may help to improve the left ventricular diastolic function and effectively inhibit left ventrical hypertrophy.
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基本信息:
中图分类号:R541.3
引用信息:
[1]何文凯,何兆初,苏诚坚,等.阿托伐他汀钙对自发性高血压大鼠血压及左室功能的影响[J].广州医学院学报,2006(02):9-12.
基金信息:
2005年度广东省自然科学基金项目(5002313)