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本文观察20例正常人和38例非胰岛素依赖型糖尿病（NIDDM）患者（轻型30例，重型8例）治疗前后血糖、胰岛素、C肽和胰高血糖素的变化。发现两组病人血胰高血糖素显著高于正常人（P＜0．05），轻型组治疗前空腹、餐后两小时血糖显著升高、血胰岛素、c肽分别高于正常（P＜0．05）；治疗后空腹和餐后两小时血糖显著下降，胰岛素和C肽稍有升高；胰高血糖素有下降趋势，但无统计学意义。重型组治疗前组C肽显著低于正常（P＜0．05），胰高血糖素明显升高，与轻型组比较P＜0．05；治疗后胰高血糖素明显下降，其值与正常人相比P＜0．05，与轻型组比较无显著性差异。
Abstract：Changes of levels of blood glucose、 insulin, C-peptide and glucagon in blood of 38 diabetic patients before and after treatment were observed. Among those patients, 30 cases were mild NIDDM, 8 cases were serious NIDDM. 20 healthy persons were also observed for comparison. We found the levels of glucagon in both groups of patients were obviously higher than those of the healthy persons (P<0.05). In patients of mild group before treatment, the levels of blood glucose before and after meals were obviously higher. The levels of blood insulin and C-peptide were higher than those of healthy persons (P<0.05). Afer treatment,the levels of blood glucose before and after meals were obviously decreased, and the levels of blood insulin and C-peptide were a bit increased, glucagon were tended to decrease, but no statistic significance. In serious group before treatmnet,the levels of blood C-peptide were obviously lower than normal(P<0.05), and the levels of glucagon were increased obviously in comparison with mild group (P<0.05). Afer treatment, the levels of blood glucagon were decreased obviously,in comparison with healthy persons (P<0.05). It had no statistic signficance in comparison with the type of mild group.
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基本信息:
中图分类号:R587.1
引用信息:
[1]宫雅南,庄万江.糖尿病患者治疗前后血胰岛素C肽和胰高血糖素变化[J].广州医学院学报,1994(05):56-59.
1994-10-15
1994-10-15