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本研究观察了大鼠在妊娠期间饮用酒精对新生仔鼠脑细胞增殖的影响。从孕1天至分娩,给孕大鼠喂养含酒糟的流质饮食,对照组、低浓度酒精组和高浓度酒精组其食物中酒精源性热卡占总热卡的比例分别为0％,18％和36％。应用流式细胞术检测新生1天大鼠大脑、小脑和脑干组织的脑细胞增殖。在高浓度酒精组,大脑和脑干细胞增殖明显低于对照组和低浓度酒精组。结果提示酒精干扰新生仔代脑细胞增殖可能是导致“胎儿酒精中毒综合征”患儿智力和行为受损的病理机制之一。
Abstract：Effect of prenatal alcohol exposure on brain cell proliferation in new born rats was investigated by means of flow cytometry. The pregnant rats consumed an ethanol -containing liquid diet containing 0%(control group), 18%(low -dose ethanoDand 36%(high -dose ethanol) ethanol-derived calories from first day of gestation until parturition . The level of cellular proliferation of cerebrum,cerebellum and brain -stem was analyzed in the 1 -day old tats. Cell proliferation activity of cerebrum and brain -stem in high -dose group was significantly decreased as compared to the control or low -dose group. Our observations suggested that alcohol -related derangement in the patterns of proliferation of the brain cells probably contributed the pathogenesis of the intellectual and behavioral impairment in FAS children.
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基本信息:
中图分类号:R99
引用信息:
[1]何旦莎,吕明雄.含酒精食物喂养孕大鼠对其新生仔代的脑细胞增殖的影响[J].广州医学院学报,1995(02):1-4.
1995-04-15
1995-04-15