广州医科大学学报

目的:观察胰岛素泵泵入诺和锐控制脑出血后高血糖反应的临床效果和安全性。方法:选取2006年3月至2007年11月肇庆市怀集县人民医院收治的64例急性脑出血后应激性高血糖患者作为对照组(皮下注射诺和灵),2007年12月至2009年6月收治的64例作为研究组(胰岛素泵泵入诺和锐)。统计两组血糖控制时间、胰岛素用量、低血糖发生次数;根据GOS评估法判定疗效。结果:观察组治疗后血糖控制时间早于对照组,胰岛素用量、低血糖发生次数低于对照组(P<0.05)。与对照组相比较,观察组恢复良好、中度残疾患者增加,重度残疾、长期昏迷及死亡患者减少(P<0.05)。结论:胰岛素泵泵入诺和锐对于控制脑出血后高血糖反应安全有效,可以明显改善预后。

Objective: To investigate the clinical effect and safety of pumping Aspart by insulin pump for the control of hyperglycemia after cerebral hemorrhage. Methods: Sixty-four cases with stress hyperglycemia( SHG)after acute cerebral hemorrhage hospitalized between March 2006 and November 2007,and 64 hospitalized between December 2007 and June 2009 in Huaiji People's Hospital of Zhaoqing city were divided into the control group( subcutaneous injection with Aspart) and the study group( pumping Aspart by insulin pump),respectively. The blood glucose control time,insulin dosage and the frequency of hypoglycemia of the two groups statistically analyzed,and the effects were evaluated by GOS. Results: Faster blood glucose control time,and lower insulin dosage and frequency of hypoglycemia were found in the study group compared with those in the control group after the treatment( P < 0. 05). Compared with the control group,well recovered and moderate disabled patients were increased,and severe disabled,long-term comatose and died patients were decreased in the study group( P < 0. 05). Conclusion  Pumping Aspart by insulin pump is safe and effective to control hyperglycemia after cerebral hemorrhage,and can significantly improve the prognosis.