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目的:探讨乙型肝炎患者血清腺苷酸脱氨酶(ADA)、透明质酸(HA)、层黏蛋白(LN)、Ⅳ型胶原(C-Ⅳ)及Ⅲ型前胶原(PCⅢ)检测的临床意义。方法:选择选择2011年8月至2012年12月海南省人民医院收治的30例乙型肝炎患者作为观察组.同期38例健康体检者作为正常对照组.分别检测两组血清ADA活性,HA、LN、C-Ⅳ、PCⅢ水平。结果:观察组患者血清ADA活性、HA、LN、C-Ⅳ、PCⅢ水平明显高于正常对照组(P<0.01)。结论:乙型肝炎患者血清ADA的活性与HA、LN、C-Ⅳ、PCⅢ水平的变化可反映肝脏损伤程度和肝纤维化趋势,对早期诊断治疗及预后判断有重要的临床价值。
Abstract：Objective:To investigate the clinical significance of measurement of serum adenosine deaminase(ADA),hyaluronic acid(HA),laminin(LN),type Ⅳ collagen(C-Ⅳ) and type Ⅲ procollagen(PC Ⅲ) in hepatitis B.Methods;We assayed the ADA activity and the levels of HA,LN,C-1V and PCII1 in 30 patients with hepatitis B who were admitted to Hainan People's Hospital between August 2011 and December 2012(observation group) and 38 volunteers scheduled for health check-up(control group).Results;The observation group was associated with markedly increased ADA activity and higher levels of HA,LN,C-IV and PCIU(all P<0.01).Conclusion;Changes in the ADA activity and the levels of HA,LN,C-IV and PCIll may sensitively reflect the degree of liver injury and fibrosis and should be considered worthwhile for promoting early diagnosis and treatment and predicting the prognosis of hepatitis B.
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基本信息:
中图分类号:R575.2
引用信息:
[1]蔡坤,王福利.乙型肝炎血清腺苷酸脱氨酶与肝纤维化血清标志物测定的临床意义[J].广州医学院学报,2013,41(04):45-46+49.