广州医科大学学报

目的:探讨骨钙素(sOC)、降钙素(CT)、睾酮(T)及甲状旁腺激素(PTH)等钙调节激素在老年男性骨质疏松症发生发展及其相互作用。方法:用放射免疫分析法检测本院114例老年男性患者血清中的sOC、CT、T及PTH水平,同时行骨密度检测。用双能X线骨密度仪(DEXA)测定患者腰椎、股骨颈、Ward’s三角区的骨密度,对结果进行分析。结果:随着年龄增加,不同年龄组骨量减少、骨质疏松症的发生率(15.23%,22.18%,33.75%)呈显著上升趋势(P<0.05),且sOC、CT、T逐渐减少,PTH逐渐增加(P<0.05)。结论:年龄增长、钙调节激素变化是老年男性骨质疏松发生的主要因素之一;检测钙调节激素水平,对预测老年男性骨质疏松高危状态有一定参考价值。

Objective: To investigate among elderly men with osteoporosis the roles of calcium-regulating hormones such as serum osteocalcin (sOC), calcitonin (CT), testosterone (T) and parathyroid hormone (PTH) in development and progression of the disease. Methods: 114 elderly men with osteoporosis or osteopenia were recruited to be evaluated for levels of sOC, CT, T and PTH in the serum using radio immunoassay. Measurements of bone mineral density (BMD) of the lumbar spine, femoral neck and Ward's trigone with dual energy X-ray absorptiometry were performed. Results: Along with aging, there was a trend towards reduced bone mass and rising incidence of osteoporosis (15.23%, 22.18% and 33.75%), along with a progressive decrease in sOC, CT and T, and an increase in PTH in different age groups. Conclusion: Altered calcium-regulating hormones and aging may be major risks for development of osteoporosis in elderly men. Tests of calcium regulating hormones seem to be useful to predict the risk in this population.