广州医科大学学报

目的：探讨急性非ST段抬高型心肌梗死（NSTEMI）患者术后Myo、OPG和炎症因子水平变化与心功能相关性。方法：挑选2020年9月至2022年9月于我院确诊并实施PCI手术的非ST段抬高型心肌梗死患者126例设为此次试验的观察组；另挑选同一个时间段我院实施体检的健康人员100名为此次试验的健康组；观察组患者入院后由心血管内科介入医师行PCI术，术后对两组Myo、OPG、cTnT、NT-proBNP、IL-6以及TNF-α水平做出对比以及与NYHA分级相关性做出研究。结果：观察组患者血清中Myo、OPG、NT-proBNP、cTnT、IL-6以及TNF-α水平显著高于对照组（P<0.05）；观察组患者血清中Myo、OPG、NT-proBNP、cTnT、IL-6以及TNF-α水平随着NYHA分级提高显著升高（P<0.05）；经Pearson检验，观察组患者血清中Myo、OPG、NT-proBNP、cTnT、IL-6以及TNF-α水平与NYHA分级呈正相关（P<0.05）；联合检测Myo、OPG、NT-proBNP、cTnT、IL-6以及TNF-α在NSTEMI诊断中敏感性、特异性高于任何一项的单一诊断（P<0.05）。结论：Myo、OPG、NT-proBNP、cTnT、IL-6以及TNF-α水平与NSTEMI患者心功能呈正相关，可作为判断NSTEMI发生、发展的检测指标。

Objective:To investigate the correlation between myoglobin(Myo),osteoprotegerin(OPG),and inflammatory cytokine levels after percutaneous coronary intervention(PCI)and the cardiac function in invalids with acute non-ST-segment elevation myocardial infarction(NSTEMI). Methods:Included as study subjects were 126invalids wtih NSTEMI diagnosed and subjected to PCI in our hospital between September 2020 and September 2022. A contemporary cohort of 100 health checkup subjects in our hospital were included as the healthy control group. After admission,the invalids in the study group underwent PCI by our interventional cardiologists. After PCI,the two groups were compared for levels of Myo,OPG,cardiac troponin T(cTnT),amino-terminal fragment of pro-brain natriuretic peptide(NT-proBNP),interleukin(IL)-6 and tumor necrosis factor-α(TNF-α),as well as their correlation with New York Heart Association(NYHA)classification. Results:The serum levels of Myo,OPG,NT-proBNP,cTnT,IL-6 and TNF-α in the study group were significantly higher than those in the control group(P<0.05). In the study group,the serum levels of Myo,OPG,NT-proBNP,cTnT,IL-6 and TNF-α increased dramatically along with higher NYHA classification(P<0.05). By Pearson's correlation analysis,the serum levels of Myo,OPG,NT-proBNP,cTnT,IL-6 and TNF-α in the study group were positively correlated with NYHA classifications(P<0.05). The sensitivity and specificity of combined testing for Myo,OPG,NT-proBNP,cTnT,IL-6 and TNF-α in diagnosing NSTEMI were higher than any of these indicators used alone(P<0.05). Conclusion:Myo,OPG,NT-proBNP,cTnT,IL-6,and TNF-α levels positively correlate with cardiac function in NSTEMI invalids,and can be used as indicators in identifying the onset and progression of NSTEMI.