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目的:评价初诊上皮性卵巢癌患者血清CA-125水平与其预后的关系。方法:回顾性分析145例初诊上皮性卵巢癌患者血清CA-125水平与FIGO分期、肿瘤细胞分化程度的关系。采用Kaplan-Meier生存曲线分析初诊患者血清CA-125水平与其远期预后的关系,并利用Cox风险比例模型分析血清CA-125水平与患者远期预后的独立相关性。结果:初诊卵巢癌患者血清CA-125水平随着FIGO分期的增加而逐渐增高,随着肿瘤细胞分化程度的增加而逐渐降低。血清CA-125≤194.10kU/L的患者,其远期预后优于血清CA-125>194.10kU/L。Cox风险比例模型表明,在校正了年龄,FIGO分期,肿瘤细胞分化程度等因素后,血清CA-125水平增高(>194.10kU/L)与患者远期预后的风险比为1.750(95%CI:1.1053～2.773)。结论:血清CA-125水平是上皮性卵巢癌患者预后的独立危险因子。
Abstract：Objective:To evaluate the prognosis value of initial serum CA-125 level in epithelial ovarian cancer patients.Methods:The association between initial serum CA-125 level with FIGO grade,as well as tumor cell differentiation grade,was retrospectively analyzed in 145 epithelial ovarian cancer patients.Kaplan-Meier survive curve and Cox proportional hazard model were used to assess the prognosis value of initial serum CA-125 level in epithelial ovarian cancer patients.Results:The serum CA-125 level in epithelial ovarian cancer patients was increased as the progress of FIGO grade,but decreased as the progress of tumor cell differentiation grade. Lower serum CA-125 level(≤194.10kU/L) was associated with higher survive rate than that of higher serum CA-125 level.The serum CA-125 level was associated with long term survival rate after adjusted for age,FIGO grades,tumor cell differentiation grade etc.Conclusion:The initial serum CA-125 level was an independent prognosis factor for epithelial ovarian cancer patients.
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基本信息:
中图分类号:R737.31
引用信息:
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