广州医科大学学报

报道13例诊断为咳嗽变异型哮喘病人，男4例，女9例，平均年龄40．77±8．37岁，发病时间最短3个月，最长27年。13例病人均有夜间咳喘发作的特点。在应用其它解痉平喘、止咳、激素等药治疗，症状无改善，夜间阵咳后喘息不能控制的情况下，夜间加用普鲁卡因静脉点滴一次，每次300～400mg加入500毫升液体中，滴速2～3ml／分，疗程为7～10天。结果临床控制9例，显效2例，无效2例。总有效率为别．62％。无效的2例均为哮喘持续状态，病史长且合并有严重的下呼吸道感染。疗程中无明显的副作用发生。所以普鲁卡因对咳嗽变异型哮喘的夜间发作性喘息患者的治疗有较好的近期疗效。是值得可取的治疗方法。但必须适当选择病例，用药、时间及速度是十分重要的。

13 cases were diagnosed as coughing asthma (M: 4, F: 9, mean age: 40. 77±8. 37 years)with the shortest history of 3 months and the longest 27 years. All of these 13 patients have onsets of nocturnal cough and wheeze. They all received bronchial dilator such as fy udrenergics and steroid as well as antitussive, but the symptoms were out of control. Procaine 300-400 mg in 500ml of solution was used intravenously once a night with the flow rate of 2- 3ml/min and the duration of 7-10 days. The results showed that 9 cases were under control, 2 greatly re1ieved and 2 failed with total effective rate of 84.62%. The causes of failure in the two cases were 1, A long history of asthma, 2, Status asthmaticus, 3, Complicateds with severe infection of lower respiratory tract. No side effects were found. Procaine shows better short-term effect on dealing with nocturnal onsets of coughing asthma- It is worth being recommended under proper case selection, infusion time and flow rate.