广州医科大学学报

目的:探讨益生菌治疗肠易激综合征(IBS)的安全性和有效性。方法:收集本院本科2005年5月到2011年6月的肠易激综合征患者240名,分为益生茵组(用益生菌+常规治疗,120例),对照组(常规治疗,120例),比较两组疗效及不良反应。结果:治疗3个疗程后,益生菌组115例有效,有效率95.83%,常规治疗组97例有效,有效率80.83%(P<0.05),未见不良反应。结论:益生菌能有效缓解IBS患者的症状且不良反应较少。

Objective:To investigate the safety and efficacy of probiotics in patients with irritable bowel syndrome(IBS).Methods:A total of 240 patients with IBS who presented to our department between May 2005 and June 2011 were included and assigned to the probiotics groups(treated on probiotics and conventional therapy,n-120) or the control group(conventional therapy alone,n=120).Therapeutic efficacy and adverse events were compared between groups.Results:After 3 courses of treatment,115 cases of the probiotic group showed improvement(rate of response;95.83%),compared with 97 cases(rate of response;80.83%) of the control group(P<0.05).No adverse events were found in either group.Conclusion:Probiotics can effectively alleviate the symptoms of IBS and are well-tolerated.