广州医科大学学报

目的:探讨血清胱抑素C(Cys-C)检测对老年慢性肾衰竭(CRF)的临床意义。方法:选择98例老年CRF患者作为观察组,其中,Ⅰ期33例,Ⅱ期28例,Ⅲ期21例,Ⅳ期16例。另选取同期在我院作健康体检的老年人36例作为对照组。分别采血及检测Cys-C、肌酐(Scr)和尿素氮(BUN)水平并进行比较分析。结果:观察组血清Cys-C、Scr及BUN水平均显著高于对照组(P均<0.01)。观察组中Ⅰ期、Ⅱ期、Ⅲ期和Ⅳ期患者血清Cys-C、Scr及BUN水平比较,差异均有统计学意义(Ⅰ期组<Ⅱ期组<Ⅲ期组<Ⅳ期组,P均<0.01)。在Ⅰ期患者中,Cys-C检测的阳性率明显高于Scr和BUN的阳性率(P<0.05和P<0.01)。结论:血清Cys-C可作为早期诊断老年CRF的敏感指标,并对判断病情严重程度有重要价值。

Objective: To explore the clinical significance of detecting serumcystatin C( Cys-C) in senile patients with chronic renal failure( CRF). Methods: 98 senile patients with CRF were served as observation group,including periodⅠof 33 cases,period Ⅱ of 28 cases,period Ⅲ of 21 cases and period Ⅳ of 16 cases.36 healthy senile people were served as control group. The levels of serum Cys-C,Scr and BUN were detected and compared. Results The levels of serum Cys-C,Scr and BUN of observation group were significantly higher than those of the control( three P < 0. 01). There were significantly differences among periodⅠ,Ⅱ,Ⅲ,Ⅳ patients of levels of Cys-C,Scr and BUN( periodⅠgroup < periodⅡgroup < period Ⅲ group < period Ⅳgroup,all P <0. 01). Positive rate of Cys-C detection in periodⅠgroup was significantly higher than those of Scr and BUN( P< 0. 05 or P < 0. 01). Conclusion: Serum Cys-C can serve as a sensitive indicator to early diagnosis of senile CRF patients,and it have important value to evaluate the severity of condition.