广州医科大学学报

目的：探讨D?二聚体（D?D）、三酰甘油（TG）联合脐血流参数预测子痫前期患者母婴不良结局的价值。方法：收集2019年12月至2023年12月本院收治的子痫前期患者143例，按母婴结局分为不良结局组（n=68）和非不良结局组（n=75）。比较两组D?D、TG水平及脐动脉收缩期峰值流速与舒张末期流速（S/D）比值，分析D?D、TG及脐动脉S/D比值判断母婴不良妊娠结局的价值。结果：不良结局组D?D、TG水平及脐动脉S/D比值均高于非不良结局组（均P<0.05）。多因素Logistic回归分析显示，D?D、TG水平及S/D比值异常升高是子痫前期患者母婴不良结局的危险因素（均P<0.05）。D?D+TG+S/D比值联合检测判断子痫前期患者母婴不良结局的AUC值为0.846(P<0.001)，高于单项或两项指标联合检测的AUC值。结论：子痫前期患者发生母婴不良结局的风险较高，监测D?D、TG水平及脐动脉S/D比值对判断不良妊娠结局具有较高的准确性。

Objective:To explore the value of D?dimer(D?D),triglyceride(TG)combined with umbilical blood flow parameters in predicting maternal and fetal adverse outcomes in patients with preeclampsia.Methods:A total of143 patients with preeclampsia admitted to our hospital from December 2019 to December 2023 were collected and divided into adverse outcome group(n=68)and non?adverse outcome group(n=75)according to maternal and infant outcomes. The levels of D?D and TG,and the ratio of peak systolic velocity to end diastolic velocity(S/D)of umbilical artery were compared between the two groups,and the value of D?D,TG and umbilical artery S/D ratio in determining maternal and infant adverse pregnancy outcomes was analyzed.Results:The levels of D?D,TG and umbilical artery S/D ratio in the adverse outcome group were higher than those in the non ? adverse outcome group(all P<0.05).Multivariate logistic regression analysis showed that abnormal increase levels of D?D,TG and S/D ratio were risk factors for maternal and infant adverse outcomes in preeclampsia patients(all P<0.05). The AUC value of combined detection of D?D+TG+S/D ratio in determining maternal and infant adverse outcomes in preeclampsia patients was 0.846(P<0.001),which was higher than the AUC values of single or combined detection of two indicators.Conclusion:Patients with preeclampsia have a higher risk of adverse maternal and infant outcomes. It has a high accuracy in determining the adverse pregnancy outcomes by monitoring the levels of D?D,TG,and umbilical artery S/D ratio.